Aspiration of autologous cells
(=Bone marrow aspirate extract = BoneMarrowAspirateEXtract = BMAX®)
and targeted return to the knee joint -
for more activity and less pain
Holistic bone marrow harvesting – like the body's own healing process: With our patented technology, we harvest the entire bone marrow from the iliac crest – just as the body uses it for its natural healing process.
Our method not only harvests mononuclear cells, but the entire regenerative environment – including growth factors, proteins and extracellular vesicles.
Compared to conventional medical products, we achieve a significantly higher yield – for maximum regenerative effect.
Harvesting and injection are performed gently and on an outpatient basis under local anesthesia.
Our technology works directly on the patient – without expensive centrifuges or special kits.
"Since 1995, I have been researching joint wear with large international research groups. In 2018, I developed a milestone in the harvesting technique with the MarrowX® method. As a result, we now have a 90% success rate after 4-5 years for severe joint wear (KL grade III and IV) and can avoid or delay knee replacement."
While conventional "stem cell therapies" require approximately 60-200 ml of bone marrow aspirate, of which 95-98% is centrifuged away, we work with a much smaller amount of significantly more concentrated bone marrow, which, thanks to our technology, is immediately available under local anesthesia and without centrifugation.
This saves the patient anesthesia and the practitioner time and money for a set and a centrifuge, both of which are no longer necessary.
We have proven to have 5-10 times more mononuclear cells (also called "stem cells") than any of our competitors. It is widely known and scientifically proven that in this form of therapy, the number of cells is related to a positive outcome.
A natural, complete cell therapy - directly from your own bone marrow, as the body intended
4-year results with > 90% satisfaction and without knee prosthesis even with severe (KL grade III and IV) wear.
Some of the cells actually become cartilage tissue, and it has been proven several times by various authors that the cartilage increases in volume and the hyaline portions increase, not just the fibrocartilage portions.
Another important effect is the release of vesicles/secretomes, which are messenger substances that the stem cells send to the target cells at the request of the target tissue, sometimes also by forming special transmission structures (tubules).
The third effect is a healing effect on the target tissue, with an upregulation of cartilage-protecting messenger substances (proteins) and a reduction of pro-inflammatory interleukins (proteins). This can be detected and quantified based on the activated genes in the target cells (cartilage and synovial membrane).
A recently described effect is that via EVs (extracellular vesicles), which are substances that are packaged in cell membranes and diffuse between cells in the so-called "third space" to the damaged tissue.
Since we work without centrifugation, our method offers the advantage that all of these mechanisms of action are used unchanged and as intended by nature.
Our researchers therefore work in the laboratory both in cell experiments with the cellular component and on the proteins and messenger substances (interleukins) and also have experience with extracellular vesicles.
In combination with our MarrowX® app, we hope to be able to provide a prognosis in the future as to when our therapy is best used. Until then, however, we still need a lot of data from patients who have already undergone surgery.
We therefore claim to have the most detailed knowledge and the longest experience compared to many competitors. This is also reflected in our superior clinical results after several years.
The method of cell-based therapy with bone marrow aspirate (such as MarrowX®) has been recommended by the leading professional societies in the Western world for joint wear since 2024.
as the most important surgical scientific worldwide professional society
as the most important global cartilage research society
